Balaraman Kalyanaraman Selected Research

triphenylphosphonium

1/2022	Therapeutic Targeting of Tumor Cells and Tumor Immune Microenvironment Vulnerabilities.
10/2020	Potent inhibition of tumour cell proliferation and immunoregulatory function by mitochondria-targeted atovaquone.
12/2017	Modified Metformin as a More Potent Anticancer Drug: Mitochondrial Inhibition, Redox Signaling, Antiproliferative Effects and Future EPR Studies.
11/2014	A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease.
1/2013	Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model.
10/2011	Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells.
12/2010	Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model.
10/2009	A (99m)Tc-labeled triphenylphosphonium derivative for the early detection of breast tumors.

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Balaraman Kalyanaraman Research Topics

Disease

46	Neoplasms (Cancer) 05/2022 - 11/2002
11	Inflammation (Inflammations) 10/2021 - 09/2002
10	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 05/2009
10	Breast Neoplasms (Breast Cancer) 01/2020 - 08/2007
8	Parkinson Disease (Parkinson's Disease) 01/2020 - 12/2010
6	Carcinogenesis 05/2022 - 05/2010
6	Lung Neoplasms (Lung Cancer) 05/2022 - 05/2010
6	Cardiotoxicity 01/2020 - 11/2002
6	Hypoxia (Hypoxemia) 01/2020 - 02/2011
6	Pancreatic Neoplasms (Pancreatic Cancer) 12/2017 - 05/2013
5	Carcinoma (Carcinomatosis) 01/2016 - 01/2014
4	Neoplasm Metastasis (Metastasis) 01/2020 - 09/2015
4	Cardiomyopathies (Cardiomyopathy) 01/2020 - 02/2008
3	COVID-19 10/2021 - 01/2020
3	Heart Failure 01/2020 - 02/2008
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019 - 08/2014
2	Colonic Neoplasms (Colon Cancer) 01/2018 - 01/2018
2	Cardiovascular Diseases (Cardiovascular Disease) 12/2017 - 01/2010
2	Disease Progression 10/2017 - 10/2012
2	Non-alcoholic Fatty Liver Disease 10/2017 - 07/2015
2	Reperfusion Injury 01/2013 - 09/2012
2	Myocardial Ischemia (Ischemic Heart Diseases) 01/2013 - 01/2010
2	Hypertension (High Blood Pressure) 01/2010 - 03/2002
1	Malaria 01/2022
1	Post-Acute COVID-19 Syndrome 10/2021
1	Sickle Cell Anemia (Hemoglobin S Disease) 06/2021

Drug/Important Bio-Agent (IBA)

19	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 01/2010
15	AntioxidantsIBA 01/2018 - 01/2010
11	Pharmaceutical PreparationsIBA 01/2022 - 12/2010
8	triphenylphosphoniumIBA 01/2022 - 10/2009
8	Metformin (Glucophage)FDA LinkGeneric 01/2022 - 01/2016
8	Superoxides (Superoxide)IBA 01/2020 - 03/2002
7	Oxidants (Oxidizing Agents)IBA 10/2020 - 09/2012
7	mito-carboxy proxylIBA 01/2018 - 01/2012
6	Phosphotransferases (Kinase)IBA 01/2022 - 11/2010
6	Adenosine Triphosphate (ATP)IBA 01/2020 - 05/2010
6	Proteins (Proteins, Gene)FDA Link 01/2019 - 09/2002
5	CytokinesIBA 10/2021 - 01/2013
5	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2020 - 08/2015
5	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2020 - 02/2008
5	acetovanillone (apocynin)IBA 11/2017 - 10/2012
4	honokiolIBA 05/2022 - 11/2014
4	EnzymesIBA 01/2022 - 04/2006
4	NADPH Oxidases (NAD(P)H oxidase)IBA 12/2017 - 02/2011
3	CationsIBA 01/2022 - 12/2010
3	Biological ProductsIBA 01/2022 - 01/2014
3	Atovaquone (Mepron)FDA Link 01/2022 - 01/2022
3	Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)IBA 01/2022 - 05/2010
3	Neuroprotective AgentsIBA 01/2022 - 12/2010
3	Antineoplastic Agents (Antineoplastics)IBA 06/2021 - 04/2006
3	Free RadicalsIBA 10/2020 - 08/2014
3	nitroxylIBA 01/2018 - 10/2011
3	Hypoglycemic Agents (Hypoglycemics)IBA 12/2017 - 01/2016
3	diapocyninIBA 11/2014 - 10/2012
3	mitoquinoneIBA 09/2012 - 11/2010
2	lonidamineIBA 05/2022 - 01/2019
2	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 05/2022 - 01/2019
2	RNA (Ribonucleic Acid)IBA 05/2022 - 01/2019
2	Transcription Factors (Transcription Factor)IBA 01/2022 - 04/2013
2	Hydroxyurea (Hydrea)FDA LinkGeneric 01/2022 - 06/2021
2	magnololIBA 01/2022 - 01/2020
2	Oxygen (Dioxygen)IBA 01/2020 - 08/2013
2	NitrogenIBA 01/2020 - 08/2013
2	PeroxiredoxinsIBA 01/2020 - 01/2019
2	CarbonIBA 11/2019 - 01/2017
2	Dexrazoxane (Zinecard)FDA LinkGeneric 05/2019 - 01/2013
2	Protein Isoforms (Isoforms)IBA 01/2019 - 01/2019
2	proxyl nitroxideIBA 01/2018 - 01/2017
2	Tyrosine (L-Tyrosine)FDA Link 10/2017 - 09/2002
2	Peroxynitrous Acid (Peroxynitrite)IBA 10/2017 - 07/2015
2	Leucine (L-Leucine)FDA Link 11/2014 - 08/2013
2	Reactive Nitrogen SpeciesIBA 10/2014 - 09/2002
2	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 01/2013 - 05/2009
2	3-nitrotyrosineIBA 09/2012 - 07/2011
2	Cisplatin (Platino)FDA LinkGeneric 07/2012 - 01/2012
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2011 - 08/2007
2	CholesterolIBA 10/2011 - 08/2007
2	UbiquinoneIBA 12/2010 - 11/2010
2	Caspase 3 (Caspase-3)IBA 02/2008 - 04/2006
2	ArginaseIBA 08/2007 - 05/2007
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 08/2007 - 04/2006
1	Tryptophan (L-Tryptophan)FDA Link 05/2022
1	Arginine (L-Arginine)FDA Link 05/2022
1	Polysaccharides (Glycans)IBA 05/2022
1	Proline (L-Proline)FDA Link 05/2022
1	RotenoneIBA 01/2022
1	Antimalarials (Antimalarial Agents)IBA 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	Protons (Proton)IBA 01/2022
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2022
1	Immunomodulating AgentsIBA 10/2021
1	Cytochrome P-450 CYP2E1 (CYP2E1)IBA 11/2020
1	malic acid (malate)IBA 10/2020
1	duroquinol (durohydroquinone)IBA 10/2020
1	Pyruvic Acid (Pyruvate)IBA 10/2020

Therapy/Procedure

14	Therapeutics 01/2020 - 11/2002
4	Immunotherapy 01/2022 - 03/2014
3	Chemoprevention 05/2022 - 04/2015
2	Drug Therapy (Chemotherapy) 01/2020 - 05/2019
1	Radiotherapy 06/2021